Title
Cannabis allergy : what do we know anno 2015 Cannabis allergy : what do we know anno 2015
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Basel :Springer basel ag ,
Subject
Human medicine
Source (journal)
Archiwum immunologiae et therapiae experimentalis / Academia Scientiarum Poloniae. - Warszawa
Volume/pages
63(2015) :5 , p. 327-332
ISSN
0004-069X
ISI
000361536800001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
For about a decade, IgE-mediated cannabis (marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may lead to a cannabis sensitization and/or allergy. The clinical manifestations of a cannabis allergy can vary from mild to life-threatening reactions, often depending on the route of exposure. In addition, sensitization to cannabis allergens can trigger various secondary cross-allergies, mostly for plant-derived food. This clinical entity, which we have designated as the cannabis-fruit/vegetable syndrome might also imply cross-reactivity with tobacco, latex and plant-food derived alcoholic beverages. These secondary cross-allergies are mainly described in Europe and appear to result from cross-reactivity between non-specific lipid transfer proteins or thaumatin-like proteins present in Cannabis sativa and their homologues that are ubiquitously distributed throughout plant kingdom. At present, diagnosis of cannabis-related allergies rests upon a thorough history completed with skin testing using native extracts from buds and leaves. However, quantification of specific IgE antibodies and basophil activation tests can also be helpful to establish correct diagnosis. In the absence of a cure, treatment comprises absolute avoidance measures including a stop of any further cannabis (ab)use.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/5cab4e/128165.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/7bcd12/128165.pdf
https://repository.uantwerpen.be/docman/iruaauth/3f6517/54e10904.pdf
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