|
Title
|
|
|
|
The dipeptidyl peptidases 4, 8, and 9 in mouse monocytes and macrophages : DPP8/9 inhibition attenuates M1 macrophage activation in mice
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Atherosclerosis remains the leading cause of death in Western countries. Dipeptidyl peptidase (DPP) 4 has emerged as a novel target for the prevention and treatment of atherosclerosis. Family members DPP8 and 9 are abundantly present in macrophage-rich regions of atherosclerotic plaques, and DPP9 inhibition attenuates activation of human M1 macrophages in vitro. Studying this family in a mouse model for atherosclerosis would greatly advance our knowledge regarding their potential as therapeutic targets. We found that DPP4 is downregulated during mouse monocyte-to-macrophage differentiation. DPP8 and 9 expression seems relatively low in mouse monocytes and macrophages. Viability of primary mouse macrophages is unaffected by DPP4 or DPP8/9 inhibition. Importantly, DPP8/9 inhibition attenuates macrophage activation as IL-6 secretion is significantly decreased. Mouse macrophages respond similarly to DPP inhibition, compared to human macrophages. This shows that the mouse could become a valid model species for the study of DPPs as therapeutic targets in atherosclerosis. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Inflammation. - New York
|
|
|
Publication
|
|
|
|
New York
:
2016
|
|
|
ISSN
|
|
|
|
0360-3997
|
|
|
DOI
|
|
|
|
10.1007/S10753-015-0263-5
|
|
|
Volume/pages
|
|
|
|
39
:1
(2016)
, p. 413-424
|
|
|
ISI
|
|
|
|
000370083500046
|
|
|
Pubmed ID
|
|
|
|
26454447
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (open access)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|