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Title
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The dipeptidyl peptidases 4, 8, and 9 in mouse monocytes and macrophages : DPP8/9 inhibition attenuates M1 macrophage activation in mice
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Author
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Abstract
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| Atherosclerosis remains the leading cause of death in Western countries. Dipeptidyl peptidase (DPP) 4 has emerged as a novel target for the prevention and treatment of atherosclerosis. Family members DPP8 and 9 are abundantly present in macrophage-rich regions of atherosclerotic plaques, and DPP9 inhibition attenuates activation of human M1 macrophages in vitro. Studying this family in a mouse model for atherosclerosis would greatly advance our knowledge regarding their potential as therapeutic targets. We found that DPP4 is downregulated during mouse monocyte-to-macrophage differentiation. DPP8 and 9 expression seems relatively low in mouse monocytes and macrophages. Viability of primary mouse macrophages is unaffected by DPP4 or DPP8/9 inhibition. Importantly, DPP8/9 inhibition attenuates macrophage activation as IL-6 secretion is significantly decreased. Mouse macrophages respond similarly to DPP inhibition, compared to human macrophages. This shows that the mouse could become a valid model species for the study of DPPs as therapeutic targets in atherosclerosis. |
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Language
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English
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Source (journal)
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Inflammation. - New York, N.Y., 1975, currens
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Publication
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New York, N.Y.
:
Kluwer Academic Publishers
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2016
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ISSN
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0360-3997
[print]
1573-2576
[online]
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DOI
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10.1007/S10753-015-0263-5
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Volume/pages
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39
:1
(2016)
, p. 413-424
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ISI
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000370083500046
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Pubmed ID
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26454447
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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