Title
Bacteriophage therapy : advances in formulation strategies and human clinical trials Bacteriophage therapy : advances in formulation strategies and human clinical trials
Author
Faculty/Department
Faculty of Sciences. Bioscience Engineering
Publication type
article
Publication
Subject
Biology
Engineering sciences. Technology
Source (journal)
Annual review of virology
Volume/pages
2(2015) , p. 599-618
ISSN
2327-056X
ISI
000364397900027
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Recently, a number of phage therapy phase I and II safety trials have been concluded, showing no notable safety concerns associated with the use of phage. Though hurdles for efficient treatment remain, these trials hold promise for future phase III clinical trials. Interestingly, most phage formulations used in these clinical trials are straightforward phage suspensions and not much research has focused on the processing of phage cocktails in specific pharmaceutical dosage forms. Additional research on formulation strategies and stability of phage-based drugs will be of key importance, especially with phage therapy advancing towards phase III clinical trials.
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