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Title
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Proteomics in cancer research : are we ready for clinical practice?
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Author
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Abstract
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| Although genomics has delivered major advances in cancer prognostics, treatment and diagnostics, it still only provides a static image of the situation. To study more dynamic molecular entities, proteomics has been introduced into the cancer research field more than a decade ago. Currently, however, the impact of clinical proteomics on patient management and clinical decision-making is low and the implementations of scientific results in the clinic appear to be scarce. The search for cancer-related biomarkers with proteomics however, has major potential to improve risk assessment, early detection, diagnosis, prognosis, treatment selection and monitoring. In this review, we provide an overview of the transition of oncoproteomics towards translational oncology. We describe which lessons are learned from currently approved protein biomarkers and previous proteomic studies, what the pitfalls and challenges are in clinical proteomics applications, and how proteomic research can be successfully translated into medical practice. |
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Language
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English
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Source (journal)
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Critical reviews in oncology, hematology / Chemical Rubber Company [Cleveland, Ohio] - Boca Raton, Fla
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Publication
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Boca Raton, Fla
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2015
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ISSN
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1040-8428
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DOI
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10.1016/J.CRITREVONC.2015.07.006
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Volume/pages
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96
:3
(2015)
, p. 437-448
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ISI
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000366536800005
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Pubmed ID
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26277237
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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