Title
The role of Th17 and Treg responses in the pathogenesis of RSV infection The role of Th17 and Treg responses in the pathogenesis of RSV infection
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Basel ,
Subject
Human medicine
Source (journal)
Pediatric research. - Basel
Volume/pages
78(2015) :5 , p. 483-491
ISSN
0031-3998
ISI
000363601700002
Carrier
E
Target language
Dutch (dut)
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The respiratory syncytial virus (RSV) represents the leading cause of viral bronchiolitis and pneumonia in children worldwide and is associated with high morbidity, hospitalization rate, and significant mortality rates. The immune response elicited by RSV is one of the main factors contributing to the pathogenesis of the disease. Two subsets of the cellular immune response, the T helper 17 cell (Th17) and the regulatory T-cell (Treg), and more particularly the balance between these two subsets, might play a significant role in the pathogenesis of the RSV infection. The developmental pathways of Th17 and Treg cells are closely and reciprocally interconnected and plasticity has been demonstrated from Treg toward Th17. During an RSV infection, the functions of both subsets are opposed to one another regarding viral clearance and clinical severity. Th17 and Treg cells offer a promising new view on the pathogenesis of an RSV infection and deserve further exploration.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/c0ca10/128469_2016_05_03.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/d1b805/128469.pdf
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