Title
CD70 : an emerging target in cancer immunotherapy CD70 : an emerging target in cancer immunotherapy
Author
Faculty/Department
Faculty of Medicine and Health Sciences
University Hospital Antwerp
Publication type
article
Publication
Oxford ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Pharmacology and therapeutics. - Oxford
Volume/pages
155(2015) , p. 1-10
ISSN
0163-7258
ISI
000364897500001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Over the last decades, advances in the knowledge of immunology have led to the identification of immune checkpoints, reinvigorating cancer immunotherapy. Although normally restricted to activated T and B cells, constitutive expression of CD70 in tumor cells has been described. Moreover, CD70 is implicated in tumor cell and regulatory T cell survival through interaction with its ligand, CD27. In this review, we summarize the targetable expression patterns of CD70 in a wide range of malignancies and the promising mechanism of anti-CD70 therapy in stimulating the anti-tumor immune response. In addition, we will discuss clinical data and future combination strategies.
E-info
https://repository.uantwerpen.be/docman/iruaauth/75e878/128510.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/6cabac/128510_2016_11_01.pdf
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