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Title
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In vivo measurement of transverse relaxation time in the mouse brain at 17.6 T
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Author
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Abstract
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| Purpose: To establish regional T1 and T2 values of the healthy mouse brain at ultra-high magnetic field strength of 17.6 T and to follow regional brain T1 and T2 changes with age. Methods: In vivo T1 and T2 values in the C57BL/6J mouse brain were followed with age using multislice-multiecho sequence and multiple spin echo saturation recovery with variable repetition time sequence, respectively, at 9.4 and 17.6 T. Gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid phantoms were used to validate in vivo T2 measurements. Student's t-test was used to compare mean relaxation values. Results: A field-dependent decrease in T2 is shown and validated with phantom measurements. T2 values at 17.6 T typically increased with age in multiple brain regions except in the hypothalamus and the caudate-putamen, where a slight decrease was observed. Furthermore, T1 values in various brain regions of young and old mice are presented at 17.6 T. A large gain in signal-to-noise ratio was observed at 17.6 T. Conclusions: This study establishes for the first time the normative T1 and T2 values at 17.6 T over different mouse brain regions with age. The estimates of in vivo T1 and T2 will be useful to optimize pulse sequences for optimal image contrast at 17.6 T and will serve as baseline values against which disease-related relaxation changes can be assessed in mice. |
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Language
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Dutch
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Source (journal)
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Magnetic resonance in medicine. - Orlando, Fla
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Publication
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Orlando, Fla
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2013
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ISSN
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0740-3194
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DOI
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10.1002/MRM.24533
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Volume/pages
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70
:4
(2013)
, p. 985-993
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ISI
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000325136300010
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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