Title
Prospects of magnetic resonance spectroscopy in mouse models of Alzheimer's disease Prospects of magnetic resonance spectroscopy in mouse models of Alzheimer's disease
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Biology
Human medicine
Source (journal)
Current medical imaging reviews
Volume/pages
7(2011) :1 , p. 80-87
ISSN
1573-4056
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
In vivo magnetic resonance spectroscopy is a powerful tool which can be applied non-invasively to monitor disease progression at a molecular level in the brain of human patients with Alzheimer's disease (AD) and transgenic mouse models of AD. Application of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in transgenic mouse models of AD makes it possible to follow metabolic changes and structural changes at the same time longitudinally. This review focuses on in vivo MRS studies in transgenic mouse models of AD and highlights the future impact of MRS techniques in finding crucial biomarkers of AD.