Title
Cell-free DNA : an upcoming biomarker in transplantationCell-free DNA : an upcoming biomarker in transplantation
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Laboratory Experimental Medicine and Pediatrics (LEMP)
VIB DMG - Applied Molecular Genomics
Faculteit Geneeskunde
Publication type
article
Publication
Copenhagen,
Subject
Human medicine
Source (journal)
American journal of transplantation. - Copenhagen
Volume/pages
15(2015):10, p. 2541-2551
ISSN
1600-6135
ISI
000362665400006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
After organ transplantation, donor-derived cell-free DNA (ddcfDNA) can be detected in the recipient's blood and urine. Different ddcfDNA quantification techniques have been investigated but a major breakthrough was made with the introduction of digital droplet PCR and massive parallel sequencing creating the opportunity to increase the understanding of ddcfDNA kinetics after transplantation. The observations of increased levels of ddcfDNA during acute rejection and even weeks to months before histologic features of graft rejection point to a possible role of ddcfDNA as an early, noninvasive rejection marker. In this review, we summarize published research on ddcfDNA in the transplantation field thereby elaborating on its clinical utility.
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Full text (open access)
https://repository.uantwerpen.be/docman/irua/5f19af/128769_2016_11_23.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/e2d009/128769.pdf
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