Title
Adjuvant therapy for resectable pancreatic adenocarcinoma : review of the current treatment approaches and future directions Adjuvant therapy for resectable pancreatic adenocarcinoma : review of the current treatment approaches and future directions
Author
Publication type
article
Publication
Oxford :Elsevier sci ltd ,
Subject
Human medicine
Source (journal)
Cancer treatment reviews. - London
Volume/pages
40(2014) :1 , p. 78-85
ISSN
0305-7372
ISI
000328871200009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Adenocarcinoma of the pancreas carries a uniformly poor prognosis with high rates of loco-regional as well as systemic recurrence. Outcomes remain poor, even for early stage and resectable disease. It is perceived as inherently resistant to most of the currently available treatment options. Evidence supports the need for adjuvant chemotherapy but controversy remains in relation to the use of combined therapy, novel agents and the most appropriate timing of therapy. Despite no clear consensus, mainstay of treatment following resection is based primarily on single agent gemcitabine. Promising new agents and molecules of prognostic as well as predictive value under evaluation offer intriguing data, despite issues surrounding adjuvant therapy strategies. In this article, we sought to review the different therapeutic adjuvant modalities and future directions. (C) 2013 Elsevier Ltd. All rights reserved.
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