Publication
Title
An observational study on rhabdomyolysis in the intensive care unit. Exploring its risk factors and main complication: acute kidney injury
Author
Abstract
Background: Because neither the incidence and risk factors for rhabdomyolysis in the ICU nor the dynamics of its main complication, i.e., rhabdomyolysis-induced acute kidney injury (AKI) are well known, we retrospectively studied a large population of adult ICU patients (n = 1,769). Methods: CK and sMb (serum myoglobin) and uMb (urinary myoglobin) were studied as markers of rhabdomyolysis and AKI (RIFLE criteria). Hemodialysis and mortality were used as outcome variables. Results: Prolonged surgery, trauma, and vascular occlusions are associated with increasing CK values. CK correlates with sMb (p < 0.001) and peaks significantly later than sMb or uMb. The logistic regression showed a positive correlation between CK and the development of AKI, with an OR of 2.21. Univariate logistic regression suggests that elevations of sMb and uMb are associated with the development of AKI, with odds ratios of 7.87 and 1.61 respectively. The ROC curve showed that for all three markers a significant correlation with AKI, for sMb with the greatest area under the curve. The best cutoff values for prediction of AKI were CK > 773 U/l; sMb > 368 mu g/l and uMb > 38 mu g/l respectively. Conclusions: Because it also has extrarenal elimination kinetics, our data suggest that measuring myoglobin in patients at risk for rhabdomyolysis in the ICU may be useful.
Language
English
Source (journal)
Annals of intensive care / Société de réanimation de langue française. - Berlin/Heidelberg, 2011, currens
Publication
Berlin/Heidelberg : Springer-Verlag, 2013
ISSN
2110-5820
Volume/pages
3(2013), 8 p.
Article Reference
8
ISI
000345067000002
Medium
E-only publicatie
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 17.11.2015
Last edited 07.10.2017