Publication
Title
Upper airway stimulation for obstructive sleep apnea : self-reported outcomes at 24 months
Author
Institution/Organisation
STAR Trial Investigators
Abstract
Objectives: To evaluate the long-term (24-month) effect of cranial nerve upper airway stimulation (UAS) therapy on patient-centered obstructive sleep apnea (OSA) outcome measures. Methods: Prospective, multicenter, cohort study of 126 moderate-to-severe OSA patients who had difficulty adhering to positive pressure therapy and received the surgically-implanted UAS system. Outcomes were measured at baseline and postoperatively at 12 months and 24 months, and included self- and bedpartner-report of snoring intensity, Epworth Sleepiness Scale (ESS), and Functional Outcomes of Sleep Questionnaire (FOSQ). Additional analysis included FOSQ subscales, FOSQ-10, and treatment effect size. Results: Significant improvement in mean FOSQ score was observed from baseline (14.3) to 12 months (17.3), and the effect was maintained at 24 months (17.2). Similar improvements and maintenance of effect were seen with all FOSQ subscales and FOSQ-10. Subjective daytime sleepiness, as measured by mean ESS, improved significantly from baseline (11.6) to 12 months (7.0) and 24 months (7.1). Self-reported snoring severity showed increased percentage of no or soft snoring from 22% at baseline to 88% at 12 months and 91% at 24 months. UAS demonstrated large effect size (> 0.8) at 12 and 24 months for overall ESS and FOSQ measures, and the effect size compared favorably to previously published effect size with other sleep apnea treatments. Conclusions: In a properly selected group of patients with moderate-to-severe OSA, hypoglossal cranial nerve stimulation therapy can provide significant improvement in important sleep-related quality of life outcome measures and the effect is maintained across a 2-year follow-up.
Language
English
Source (journal)
Journal of clinical sleep medicine
Publication
2016
ISSN
1550-9389
Volume/pages
12:1(2016), p. 43-48
ISI
000374135800007
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 19.11.2015
Last edited 10.10.2017
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