Title
The challenging world of biofilm physiology The challenging world of biofilm physiology
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
London :Academic press ltd-elsevier science ltd ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
Advances in microbial physiology. - London
Volume/pages
67(2015) , p. 235-292
ISSN
0065-2911
ISBN
978-0-12-803332-6
ISI
000385231800006
ISBN
978-0-12-803298-5
978-0-12-803332-6; 978-0-12-803298-5
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Worldwide, infectious diseases are one of the leading causes of death among children. At least 65% of all infections are caused by the biofilm mode of bacterial growth. Bacteria colonise surfaces and grow as multicellular biofilm communities surrounded by a polymeric matrix as a common survival strategy. These sessile communities endow bacteria with high tolerance to antimicrobial agents and hence cause persistent and chronic bacterial infections, such as dental caries, periodontitis, otitis media, cystic fibrosis and pneumonia. The highly complex nature and the rapid adaptability of the biofilm population impede our understanding of the process of biofilm formation, but an important role for oxygen-binding proteins herein is clear. Much research on this bacterial lifestyle is already performed, from genome/proteome analysis to in vivo antibiotic susceptibility testing, but without significant progress in biofilm treatment or eradication. This review will present the multiple challenges of biofilm research and discuss possibilities to cross these barriers in future experimental studies.
E-info
https://repository.uantwerpen.be/docman/iruaauth/f50c68/129019.pdf
Handle