Title
Novel amino-pyrazole ureas with potent in vitro and in vivo antileishmanial activityNovel amino-pyrazole ureas with potent in vitro and in vivo antileishmanial activity
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Department of Biomedical Sciences
Publication type
article
Publication
Washington, D.C.,
Subject
Biology
Pharmacology. Therapy
Human medicine
Source (journal)
Journal of medicinal chemistry. - Washington, D.C., 1963, currens
Volume/pages
58(2015):24, p. 9615-9624
ISSN
0022-2623
ISI
000367563100014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Visceral leishmaniasis is a severe parasitic disease that is one of the most neglected tropical diseases. Treatment options are limited and there is an urgent need for new therapeutic agents. Following an HTS campaign and hit optimization, a novel series of amino-pyrazole ureas has been identified with potent in vitro antileishmanial activity. Furthermore, compound 26 shows high levels of in vivo efficacy (>90%) against Leishmania infantum, thus demonstrating proof of concept for this series
Full text (open access)
https://repository.uantwerpen.be/docman/irua/7f7976/129219_2016_12_01.pdf
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