|
Title
|
|
|
|
Immune checkpoint modulation in colorectal cancer : whats new and what to expect
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Colorectal cancer (CRC), as one of the most prevalent types of cancer worldwide, is still a leading cause of cancer related mortality. There is an urgent need for more efficient therapies in metastatic disease. Immunotherapy, a rapidly expanding field of oncology, is designed to boost the bodys natural defenses to fight cancer. Of the many approaches currently under study to improve antitumor immune responses, immune checkpoint inhibition has thus far been proven to be the most effective. This review will outline the treatments that take advantage of our growing understanding of the role of the immune system in cancer, with a particular emphasis on immune checkpoint molecules, involved in CRC pathogenesis. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Journal of Immunology Research
| |
|
Publication
|
|
|
|
New york
:
Hindawi publishing corp
,
2015
| |
|
ISSN
|
|
|
|
2314-8861
2314-7156
| |
|
DOI
|
|
|
|
10.1155/2015/158038
| |
|
Volume/pages
|
|
|
|
(2015)
, 16 p.
| |
|
Article Reference
|
|
|
|
158038
| |
|
ISI
|
|
|
|
000364714500001
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|