Title
Immune checkpoint modulation in colorectal cancer : whats new and what to expect Immune checkpoint modulation in colorectal cancer : whats new and what to expect
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New york :Hindawi publishing corp ,
Subject
Human medicine
Source (journal)
Journal of Immunology Research
Volume/pages
(2015) , 16 p.
ISSN
2314-8861
2314-8861
Article Reference
158038
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Colorectal cancer (CRC), as one of the most prevalent types of cancer worldwide, is still a leading cause of cancer related mortality. There is an urgent need for more efficient therapies in metastatic disease. Immunotherapy, a rapidly expanding field of oncology, is designed to boost the bodys natural defenses to fight cancer. Of the many approaches currently under study to improve antitumor immune responses, immune checkpoint inhibition has thus far been proven to be the most effective. This review will outline the treatments that take advantage of our growing understanding of the role of the immune system in cancer, with a particular emphasis on immune checkpoint molecules, involved in CRC pathogenesis.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/23935e/129369.pdf
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