Publication
Title
A non-fatal self-poisoning attempt with Sildenafil
Author
Abstract
The phosphodiesterase type 5 inhibitor, sildenafil, is not generally known for its use as a self-poisoning drug. However, intoxication cases with lethal outcome have been described. The case presented here is of a 56-year-old man who claimed to have undertaken an unsuccessful suicide attempt by mono-ingestion of 65 tablets of 100 mg sildenafil. He arrived at the emergency department 24 h after intake with severe vomiting and symptoms of blurred vision. Clinical examination revealed no priapism. Of note was a sinus tachycardia of 100 bpm without signs of hypotension. To quantify the sildenafil concentration in serum, an high-performance liquid chromatography photo-diode array method was developed and validated according to European Medicines Agency guidelines. The intoxicated patient had a serum concentration of 22.2 mu g/mL sildenafil, at the time of presentation, which is far above the therapeutic peak concentration. The serum concentration further declined to 9.2 and 2.3 mu g/mL, respectively, 5 and 14 h later, revealing a biological half-life of 4.2 h. To the best of our knowledge, this patient took the highest sildenafil dose, which resulted in the highest serum concentration, ever reported. In this subject, sildenafil showed good tolerability because few symptoms occurred and only moderate supportive therapy was needed for full recovery without sequelae.
Language
English
Source (journal)
Journal of analytical toxicology / Society of Forensic Toxicologists [Mesa, Ariz.] - Niles, Ill., 1977, currens
Publication
Niles, Ill. : Preston Publications, 2015
ISSN
0146-4760 [print]
1945-2403 [online]
Volume/pages
39:7(2015), p. 572-576
ISI
000363251300012
Full text (Publishers DOI)
Full text (open access)
The author-created version that incorporates referee comments and is the accepted for publication version Available from 02.07.2017
UAntwerpen
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Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
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Creation 09.12.2015
Last edited 20.05.2017
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