Title
Low-dose fenfluramine in the treatment of neurologic disorders : experience in Dravet syndrome Low-dose fenfluramine in the treatment of neurologic disorders : experience in Dravet syndrome
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London :Sage publications ltd ,
Subject
Human medicine
Source (journal)
Therapeutic advances in neurological disorders. - London, 2008, currens
Volume/pages
8(2015) :6 , p. 328-338
ISSN
1756-2856
ISI
000364159600007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In this paper, we review the experience with fenfluramine in epileptic and other paroxysmal disorders. Since the best available data are from the treatment of Dravet syndrome, we will focus primarily on this condition. Originally fenfluramine was launched as an anorectic agent. As early as 1985, seizure reduction in children could be demonstrated in a few cases with photosensitive, self-induced epilepsy. Hereafter, a small study was launched in patients with self-induced epilepsy. Results showed a significant seizure reduction, and review of the patient data showed that 5 of the 12 patients had Dravet syndrome. During that observation period, fenfluramine was withdrawn from the market because of cardiovascular side effects associated with prescribing higher doses in combination with phentermine for weight loss. In March 2002, a Belgian Royal Decree was issued permitting further study of fenfluramine in pediatric patients with intractable epilepsy. In 2011 under the Royal Decree, a prospective study of patients with Dravet syndrome treated with low-dose fenfluramine was initiated and is currently ongoing. The initial results are promising in terms of reduction of seizure frequency and overall tolerability.
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