Publication
Title
One-year progression of diabetic subclinical macular edema in eyes with mild nonproliferative diabetic retinopathy : location of the increase in retinal thickness
Author
Institution/Organisation
EVICR net
Abstract
Purpose: To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. Methods: Forty-eight type 2 diabetic eyes/patients with mild non-proliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy Study) classified as presenting subclinical macular edema at baseline completed the 1-year follow-up period, from a sample of 194 followed in a 12-month observational and prospectivestudy(ClinicalTrials. gov identifier: NCT01145599). Automated segmentation of the retinal layers in these eyes was performed, followed by verification and correction by a human grader. Results: The highest increase in RT over the 1-year follow-up period for the 48 eyes/patients with subclinical macular edema was found in the inner nuclear layer (INL). Progression to clinical macular edema was also associated with increased thickening of other retinal layers aside from the INL. The microvascular disease activity shown by microaneurysm (MA) turn-over >= 6 was associated with progression from subclinical to clinical macular edema. Conclusions: Increases in RT occurring over a period of 1 year in diabetic eyes with mild NPDR and subclinical macular edema occur mainly in the INL. The development of clinical macular edema appears to be associated with increased thickening of other retinal layers and microvascular disease activity. (C) 2015 S. Karger AG, Basel
Language
English
Source (journal)
Ophthalmic research. - Basel
Publication
Basel : 2015
ISSN
0030-3747
Volume/pages
54:3(2015), p. 118-123
ISI
000364176600003
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.12.2015
Last edited 07.08.2017
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