Title
Long-term antibody persistence after vaccination with a 2-dose Havrix (TM) (inactivated hepatitis A vaccine) : 20 years of observed data, and long-term model-based predictions Long-term antibody persistence after vaccination with a 2-dose Havrix (TM) (inactivated hepatitis A vaccine) : 20 years of observed data, and long-term model-based predictions
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Vaccine / International Society for Vaccines. - Amsterdam
Volume/pages
33(2015) :42 , p. 5723-5727
ISSN
0264-410X
ISI
000364268500035
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Antibody persistence in two cohorts of adults, who received inactivated hepatitis A (HAV) vaccine (1440El.U; Havrix (TM); GSK Vaccines) according to a 0-6 or 0-12 month schedule in 1992-1993, has been measured annually. After 20 years, >97% of the subjects in both studies were seropositive for anti-HAV antibodies. Geometric mean concentrations in the according-to-protocol cohorts were 312 mIU/ml in 34/36 subjects vaccinated initially at 0-6 months (NCT00289757) and 317 mIU/ml in 85/86 subjects vaccinated at 0-12 months (NCT00291876). Over the whole follow-up period, seven subjects (2 + 5, respectively) lost circulating anti-HAV antibodies but mounted a strong response after HAV booster administration (1440El.U). Mathematical modelling, which was applied to assess true persistence at Year 20 (accounting for drop-outs and missing data), and to predict longer-term persistence confirmed previous estimates that seropositive anti-HAV levels would persist in >= 95% vaccinees at Year 30 and >= 90% at Year 40. (C) 2015 Elsevier Ltd.
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Full text (open access)
https://repository.uantwerpen.be/docman/irua/e51f99/129553.pdf
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