Publication
Title
The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics
Author
Abstract
KLK4 is a serine protease from the kallikrein family that is involved in cancer progression. The diphenyl phosphonate warhead is intended to bind irreversibly with serine proteases, but unexpectedly, very potent KLK4 diphenyl phosphonate inhibitors were discovered with reversible inhibition kinetics.
Language
English
Source (journal)
MedChemComm
Publication
2015
ISSN
2040-2503
2040-2511
Volume/pages
6:11(2015), p. 1954-1958
ISI
000364154000005
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.12.2015
Last edited 14.05.2017
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