Proteomics applications in **Caenorhabditis elegans** researchProteomics applications in **Caenorhabditis elegans** research
Faculty of Sciences. Biology
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Systemic Physiological and Ecotoxicological Research (SPHERE)
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Proteinchemistry, proteomics and epigenetic signalling(PPES)
Biomolecular & Analytical Mass Spectrometry (BAMS)
2015New York, N.Y., 2015
Biochemical and biophysical research communications. - New York, N.Y.
468(2015):4, p. 519-524
University of Antwerp
The free-living nematode Caenorhabditis elegans is one of the most studied models in a wide variety of research fields with applications in agro- or pharmaceutical industries. It has been used for the development of new anthelminthic drugs and was proven to yield key insights in neurodegenerative diseases and metabolic syndromes. Due to its suitability for high-throughput genetic screens, efficiency for RNA interference approaches and the availability of thousands of mutants, most studies were carried out at the genetic level. However, determining the cellular function of each gene product remains an unfinished goal in this post-genomic era. A systems biology approach focusing on the actual gene products (i.e. proteins) can help unraveling this puzzle. A fundamental pillar in this research is mass spectrometry-based proteomics. We here provide an in-depth overview of proteomics-related studies in C. elegans research, with special emphasis on the methodologies and biological applications.