Title
On the connection between the tympanic membrane and the malleus On the connection between the tympanic membrane and the malleus
Author
Faculty/Department
Faculty of Sciences. Biology
Faculty of Sciences. Physics
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Amsterdam :Elsevier science bv ,
Subject
Biology
Human medicine
Source (journal)
Hearing research. - Amsterdam
Volume/pages
340(2016) , p. 50-59
ISSN
0378-5955
ISI
000386417900007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background The tympano-mallear connection (TMC) is the soft-tissue connection between the tympanic membrane (TM) and the manubrium of the malleus. Some studies suggest that its mechanical properties may have a substantial influence on the mechanics and transfer function of the middle ear. However, relatively little is known about the dimensions of the TMC and its variability among individuals. Method Thirteen samples were collected from human temporal bones, consisting of only the malleus and the TM. They were imaged using μCT without contrast enhancing agent. From the μCT images, the TMC dimensions were measured in both anteriorposterior direction (TMC width) and medial-lateral direction (TMC thickness). Three selected samples were examined using histological microscopy. Results Both TMC width and thickness featured a large variability among individuals. The minimal TMC width along the manubrium for different individuals covered a range between 83 and 840 μm. The minimal thickness ranged from 48 to 249 μm and the maximal thickness from 236 to 691 μm. Histological sections showed that the TMC consists of a narrow core of dense regular connective tissue, surrounded by loose connective tissue. In some samples, either of these two components was absent in the TMC at some manubrium locations. The configuration of these components varied among the samples as well. Conclusion Our data confirm that a large inter-individual variability exists in the properties of the TM-malleus connection in humans in terms of its dimensions, tissue composition and configuration. Average data and their variability margins will be useful input for testing the importance of the TMC in finite element models.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/7f50a1/130006.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/e5d717/130006.pdf
Handle