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Title
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uses a timely resurgent current to secure action potential repolarization
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Author
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Abstract
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| High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system. Voltage-dependent Kv3 channels play an important role in this process thanks to their high activation threshold and fast closure kinetics, which reduce the neurons refractory period. However, premature Kv3 channel closure leads to incomplete membrane repolarization, preventing sustainable AP propagation. Here, we demonstrate that Kv3.1b channels solve this problem by producing resurgent K+ currents during repolarization, thus ensuring enough repolarizing power to terminate each AP. Unlike previously described resurgent Na+ and K+ currents, Kv3.1bs resurgent current does not originate from recovery of channel block or inactivation but results from a unique combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation. These distinct properties are readily transferrable onto an orthologue Kv channel by transplanting the voltage-sensors S3S4 loop, providing molecular insights into the mechanism by which Kv3 channels contribute to high-frequency AP transmission. |
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Language
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English
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Source (journal)
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Nature communications
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Publication
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2015
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ISSN
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2041-1723
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DOI
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10.1038/NCOMMS10173
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Volume/pages
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6
(2015)
, 12 p.
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Article Reference
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10173
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ISI
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000367574200005
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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