Title
<tex>$K_{v}3.1$</tex> uses a timely resurgent <tex>$K^{+}$</tex> current to secure action potential repolarization <tex>$K_{v}3.1$</tex> uses a timely resurgent <tex>$K^{+}$</tex> current to secure action potential repolarization
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Nature communications
Volume/pages
6(2015) , 12 p.
ISSN
2041-1723
2041-1723
Article Reference
10173
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system. Voltage-dependent Kv3 channels play an important role in this process thanks to their high activation threshold and fast closure kinetics, which reduce the neurons refractory period. However, premature Kv3 channel closure leads to incomplete membrane repolarization, preventing sustainable AP propagation. Here, we demonstrate that Kv3.1b channels solve this problem by producing resurgent K+ currents during repolarization, thus ensuring enough repolarizing power to terminate each AP. Unlike previously described resurgent Na+ and K+ currents, Kv3.1bs resurgent current does not originate from recovery of channel block or inactivation but results from a unique combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation. These distinct properties are readily transferrable onto an orthologue Kv channel by transplanting the voltage-sensors S3S4 loop, providing molecular insights into the mechanism by which Kv3 channels contribute to high-frequency AP transmission.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/775d07/130048.pdf
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