Title
Triple-modal imaging of magnetically-targeted nanocapsules in solid tumours in vivo Triple-modal imaging of magnetically-targeted nanocapsules in solid tumours in vivo
Author
Faculty/Department
Faculty of Sciences. Physics
Publication type
article
Publication
Wyoming, N.S.W :Ivyspring International Publisher ,
Subject
Physics
Human medicine
Source (journal)
Theranostics. - Wyoming, N.S.W, 2011, currens
Volume/pages
6(2016) :3 , p. 342-356
ISSN
1838-7640
ISI
000377797200005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/5d3203/130058.pdf
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