Publication
Title
Genome sequence of the tsetse fly (**Glossina morsitans**) : vector of African trypanosomiasis
Author
Institution/Organisation
IGGI
Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/ chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
Language
English
Source (journal)
Science / American Association for the Advancement of Science [Washington, D.C.] - Washington, D.C.
Publication
Washington, D.C. : 2014
ISSN
0036-8075
1095-9203
Volume/pages
344:6182(2014), p. 380-386
ISI
000334867800033
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 13.01.2016
Last edited 18.07.2017