Title
Genome sequence of the tsetse fly (**Glossina morsitans**) : vector of African trypanosomiasisGenome sequence of the tsetse fly (**Glossina morsitans**) : vector of African trypanosomiasis
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Washington, D.C.,
Subject
Engineering sciences. Technology
Source (journal)
Science / American Association for the Advancement of Science. - Washington, D.C.
Volume/pages
344(2014):6182, p. 380-386
ISSN
0036-8075
ISI
000334867800033
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/ chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
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https://repository.uantwerpen.be/docman/iruaauth/cd7d68/130114.pdf