Title
Current status of vaccination against African trypanosomiasis Current status of vaccination against African trypanosomiasis
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Parasitology. - London, 1908, currens
Volume/pages
137(2010) :14 , p. 2017-2027
ISSN
0031-1820
ISI
000284702200006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology.
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