Title
Lipophilicity of PCBs and fatty acids determines their mobilisation from blubber of weaned northern elephant seal pupsLipophilicity of PCBs and fatty acids determines their mobilisation from blubber of weaned northern elephant seal pups
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Research group
Toxicological Centre
Publication type
article
Publication
Amsterdam,
Subject
Chemistry
Biology
Source (journal)
The science of the total environment. - Amsterdam
Volume/pages
541(2016), p. 599-602
ISSN
0048-9697
ISI
000365289300064
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Polychlorinated biphenyls (PCBs) exhibit lipophilic properties that lead to their bioaccumulation in adipose tissue. Following PCB exposition, northern elephant seals (Mirounga angustirostris) concentrate high amounts of these pollutants in their large adipose tissue stores. During lipolytic periods such as the post-weaning fast, fatty acids (FAs), which form triglycerides, and PCBs are both mobilised from adipose tissue. Our results showed that the degree of lipophilicity of FAs and PCBs impacted their release: the more lipophilic FAs and PCBs tended to be more conserved in blubber over the fast than the less lipophilic ones. This led to an enrichment of more lipophilic compounds within adipocytes with the progression of the fast. Life history patterns that include fasting may thus influence the profile of blubber lipids and contaminants. (C) 2015 Elsevier B.V. All rights reserved.
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