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Title
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Relevance of retinal thickness changes in the OCT inner and outer rings to predict progression to clinical macular edema : an attempt of composite grading of macular edema
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Author
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Institution/Organisation
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Evicr Net
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Abstract
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| Purpose: To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. Methods: A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes/patients using Cirrus SD-OCT and 166 eyes/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. Results: A total of 317 eyes/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). Conclusions: A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value. (C) 2015 S. Karger AG, Basel |
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Language
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English
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Source (journal)
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Ophthalmic research. - Basel
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Publication
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Basel
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2016
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ISSN
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0030-3747
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DOI
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10.1159/000441110
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Volume/pages
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55
:1
(2016)
, p. 19-25
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ISI
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000366337200003
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Pubmed ID
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26555067
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Full text (Publisher's DOI)
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