Title 



Statistical mechanics of the human placenta : a stationary state of a nearequilibrium system in a linear regime
 
Author 



 
Abstract 



All nearequilibrium systems under linear regime evolve to stationary states in which there is constant entropy production rate. In an open chemical system that exchanges matter and energy with the exterior, we can identify both the energy and entropy flows associated with the exchange of matter and energy. This can be achieved by applying statistical mechanics (SM), which links the microscopic properties of a system to its bulk properties. In the case of contractile tissues such as human placenta, Huxley's equations offer a phenomenological formalism for applying SM. SM was investigated in human placental stem villi (PSV) (n = 40). PSV were stimulated by means of KCl exposure (n = 20) and tetanic electrical stimulation (n = 20). This made it possible to determine statistical entropy (S), internal energy (E), affinity (A), thermodynamic force (A/T) (T: temperature), thermodynamic flow (v) and entropy production rate (A/T x v). We found that PSV operated near equilibrium, i.e., A < < 2500 J/mol and in a stationary linear regime, i.e., (A/T) varied linearly with v. As v was dramatically low, entropy production rate which quantified irreversibility of chemical processes appeared to be the lowest ever observed in any contractile system.   
Language 



English
 
Source (journal) 



PLoS ONE  
Publication 



2015
 
ISSN 



19326203
 
Volume/pages 



10:11(2015), 13 p.
 
Article Reference 



e0142471
 
ISI 



000365070700041
 
Medium 



Eonly publicatie
 
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