Title
Statistical mechanics of the human placenta : a stationary state of a near-equilibrium system in a linear regime Statistical mechanics of the human placenta : a stationary state of a near-equilibrium system in a linear regime
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Subject
Engineering sciences. Technology
Source (journal)
PLoS ONE
Volume/pages
10(2015) :11 , 13 p.
ISSN
1932-6203
1932-6203
Article Reference
e0142471
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
All near-equilibrium systems under linear regime evolve to stationary states in which there is constant entropy production rate. In an open chemical system that exchanges matter and energy with the exterior, we can identify both the energy and entropy flows associated with the exchange of matter and energy. This can be achieved by applying statistical mechanics (SM), which links the microscopic properties of a system to its bulk properties. In the case of contractile tissues such as human placenta, Huxley's equations offer a phenomenological formalism for applying SM. SM was investigated in human placental stem villi (PSV) (n = 40). PSV were stimulated by means of KCl exposure (n = 20) and tetanic electrical stimulation (n = 20). This made it possible to determine statistical entropy (S), internal energy (E), affinity (A), thermodynamic force (A/T) (T: temperature), thermodynamic flow (v) and entropy production rate (A/T x v). We found that PSV operated near equilibrium, i.e., A < < 2500 J/mol and in a stationary linear regime, i.e., (A/T) varied linearly with v. As v was dramatically low, entropy production rate which quantified irreversibility of chemical processes appeared to be the lowest ever observed in any contractile system.
E-info
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Full text (open access)
https://repository.uantwerpen.be/docman/irua/523b19/130267.pdf
Handle