Title
Dosage form data used for estimating pediatric antibiotic use Dosage form data used for estimating pediatric antibiotic use
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Wien ,
Subject
Pharmacology. Therapy
Source (journal)
Scientia pharmaceutica. - Wien
Volume/pages
83(2015) :3 , p. 511-518
ISSN
0036-8709
ISI
000365399700009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We aimed to report a simple estimation method to enable quantification of pediatric antibiotic exposure in large aggregated datasets. Secondly, we aimed to quantify and benchmark Hungarian pediatric antibiotic use. First we intended to examine whether a correlation existed between dosage form data and the patient's age. Therefore, issued prescriptions were analyzed in pharmacies. As a correlation was found between the share of liquid oral antibacterial products and the rate of pediatric antibiotic prescriptions (R=0.884; p<0.001), we extrapolated this finding to a large aggregated dataset and estimated that 34.6% of prescriptions were issued for pediatric cases (95% confidence interval: 19.7-60.0). Taking into account the demography of the population, children were exposed to antibiotics three times more often than adults with a corresponding annual prescription rate of 2.6. We demonstrated that simple drug-related data can be linked to a patient-related measure as we found strong associations between dosage form data and patients' age. Based on this association, massive pediatric antibiotic exposure was found. Due to the general availability of dosage form data and the ease of the estimation method, the reported concept can be used to quantify pediatric antibiotic use in large aggregated datasets or when age stratification is absent.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/f3b5cb/130333.pdf
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