Title
Schizophrenia-associated MIR204 regulates noncoding RNAs and affects neurotransmitter and ion channel gene setsSchizophrenia-associated MIR204 regulates noncoding RNAs and affects neurotransmitter and ion channel gene sets
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
VIB DMG - Neurogenetics Group
VIB DMG - Applied Molecular Genomics
VIB DMG - Translational Neurobiology
Publication type
article
Publication
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
PLoS ONE
Volume/pages
10(2015):12, 15 p.
ISSN
1932-6203
1932-6203
Article Reference
e0144428
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes. Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells. Analysis of the consequences of the altered miR-204 expression on the transcriptome of these cells uncovered a new mode of action for miR-204, being the regulation of noncoding RNAs (ncRNAs), including several miRNAs, such as MIR296. Furthermore, pathway analysis showed downstream effects of miR-204 on neurotransmitter and ion channel related gene sets, potentially mediated by miRNAs regulated through miR-204.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/eb8f3c/130659.pdf
E-info
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