Title
Guanidine synthesis : use of amidines as guanylating agents Guanidine synthesis : use of amidines as guanylating agents
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Weinheim ,
Subject
Physics
Chemistry
Source (journal)
Advanced synthesis and catalysis. - Weinheim
Volume/pages
358(2016) :5 , p. 826-833
ISSN
1615-4150
ISI
000372132100018
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The use of amidines for the tandem or one pot synthesis of guanidines is reported. Guanidines are obtained by oxidative rearrangement of readily available and stable amidines into carbodiimides, followed by in situ reaction with amines. The protocol can be executed under mild reaction conditions (30°C), in a green solvent (dimethyl carbonate). The amine scope is broad, including sterically hindered, oxidation sensitive and chiral amines. Examples for the synthesis of both acyclic and cyclic guanidines are provided. 2-PrOPhI byproduct, generated from the oxidant 2-PrOPhINTs, can be isolated in high yields making regeneration of the hypervalent iodine reagent possible. The utility and greenness of the synthetic method is demonstrated by a new route towards the antihypertensive drug Pinacidil. The Process Mass Intensity (PMI) of the new route is only 24% of the classical one.
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https://repository.uantwerpen.be/docman/iruaauth/93bfa1/130726.pdf
Handle