Title
Organ data from the developing Göttingen minipig : first steps towards a juvenile PBPK model
Author
Faculty/Department
Faculty of Applied Economics
Administrative Services
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Pharmacology. Therapy
Veterinary medicine
Source (journal)
Journal of pharmacokinetics and pharmacodynamics. - New York, N.Y.
Volume/pages
43(2016) :2 , p. 179-190
ISSN
1567-567X
ISI
000374704100005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The Göttingen minipig is the most commonly used pig breed in preclinical drug development in Europe and has recently also been explored for physiologically based pharmacokinetic modelling. To develop such a model, not only physiological data from adult animals but also data from juvenile animals are required, especially when using this model for paediatric drug development. Therefore, the aim of our study was to document body and organ weights (brain, heart, lungs, liver, gastrointestinal tract, spleen and kidney), lengths of the small and large intestines and pH values of the gastrointestinal tract in Göttingen minipigs from the foetal stage until the age of 5 months. Postnatal organ and body weights were fitted to regression models to find suitable equations that could be used to estimate organ weights as a function of body weight in the neonatal and juvenile Göttingen minipig. Most organs followed a non-linear growth curve during the first 5 months of life. In general, relative organ weights were the highest during the first week of life, during which the gastric pH was more alkaline than at 28 days of age.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/6022f5/130893.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/09f822/130893.pdf
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