Title
What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Boca Raton, Fla ,
Subject
Human medicine
Source (journal)
Critical reviews in oncology, hematology / Chemical Rubber Company [Cleveland, Ohio] - Boca Raton, Fla
Volume/pages
95(2015) :3 , p. 306-317
ISSN
1040-8428
ISI
000359884500005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients. Materials and methods: Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (ly-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities. Results: Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and ly-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. 03-4 hematological toxicities were also more frequent in this group. Conclusion: This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
E-info
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https://repository.uantwerpen.be/docman/iruaauth/377466/130928.pdf
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