What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis
Faculty of Medicine and Health Sciences
Boca Raton, Fla
Critical reviews in oncology, hematology / Chemical Rubber Company [Cleveland, Ohio] - Boca Raton, Fla
, p. 306-317
University of Antwerp
Background: Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients. Materials and methods: Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (ly-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities. Results: Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and ly-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. 03-4 hematological toxicities were also more frequent in this group. Conclusion: This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities. (C) 2015 Elsevier Ireland Ltd. All rights reserved.