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Title
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What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis
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Author
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Abstract
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| Background: Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients. Materials and methods: Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (ly-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities. Results: Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and ly-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. 03-4 hematological toxicities were also more frequent in this group. Conclusion: This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Critical reviews in oncology, hematology / Chemical Rubber Company [Cleveland, Ohio] - Boca Raton, Fla
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Publication
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Boca Raton, Fla
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2015
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ISSN
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1040-8428
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DOI
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10.1016/J.CRITREVONC.2015.03.010
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Volume/pages
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95
:3
(2015)
, p. 306-317
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ISI
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000359884500005
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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