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Title
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In vivo selection of **Plasmodium falciparum** Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso
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Author
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Abstract
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| Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high. |
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Language
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English
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Source (journal)
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Antimicrobial agents and chemotherapy. - Washington, D.C., 1972, currens
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Publication
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Washington, D.C.
:
American Society for Microbiology
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2015
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ISSN
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0066-4804
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DOI
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10.1128/AAC.03647-14
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Volume/pages
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59
:1
(2015)
, p. 734-737
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ISI
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000348609500101
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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