Take-home message in times of crisis : is it really better to treat with cisplatin & pemetrexed than cisplatin & gemcitabine in first line NSCLC? The power of statistical considerationsTake-home message in times of crisis : is it really better to treat with cisplatin & pemetrexed than cisplatin & gemcitabine in first line NSCLC? The power of statistical considerations
Faculty of Medicine and Health Sciences
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
2015Clare :Elsevier ireland ltd, 2015
Lung cancer: journal of the International Association for the Study of Lung Cancer / International Association for the Study of Lung Cancer [Aurora, Colo.] - Amsterdam
90(2015):3, p. 620-622
University of Antwerp
During the last decade, the cost of healthcare in oncology is world widely increased both for new drugs and even for traditional chemotherapy when new criteria for selection of patients, for example histology, are applied. Physicians are one of the principal actors in the field, having the initial responsibility to understand and interpret the scientific results in order to reduce the pharmaco-economic impact. Platinum-based doublet chemotherapy is the standard of care in advanced unselected population of Non Small cell Lung cancer (NSCLC) patients. Since the data of pemetrexed in combination with cisplatin were published, several oncologists chose this schedule as first choice in non squamous NSCLC. Another scheme, gemcitabine plus cisplatin, was the comparator for the pivotal study of pemetrexed. In this editorial we critically analyze the real data of this noninferiority study and the importance of statistical knowledge by oncologists for correct interpretation of study results. (c) 2015 Elsevier Ireland Ltd. All rights reserved.