Publication
Title
Targeting of tumor necrosis factor alpha receptors as a therapeutic strategy for neurodegenerative disorders
Author
Abstract
Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha (TNF-), and have linked it with several neurodegenerative disorders. This review describes the signaling pathways induced by TNF- via its two receptors (TNFR1 and TNFR2), and their functions in neurodegenerative processes as in Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and ischemic stroke. It has become clear that TNF- may exert divergent actions in neurodegenerative disorders, including neurodegenerative and neuroprotective effects, which appear to depend on its signaling via either TNFR1 or TNFR2. Specific targeting of these receptors is a promising therapeutic strategy for many disorders.
Language
English
Source (journal)
Antibodies
Publication
Basel : Mdpi ag, 2015
ISSN
2073-4468
Volume/pages
4:4(2015), p. 369-408
ISI
000367618700005
Full text (Publishers DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 16.02.2016
Last edited 17.05.2017
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