Title
Impact of high intensity exercise on muscle morphology in EAE rats
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Praha ,
Subject
Human medicine
Source (journal)
Physiologia Bohemoslovenica. - Praha
Volume/pages
64(2015) :6 , p. 907-923
ISSN
0862-8408
ISI
000367547900013
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) and EAE rats were divided into sedentary and exercise groups. Before onset (experiment 1, n=40) and after hindquarter paralysis (experiment 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) of tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) and brain-derived neurotrophic factor (BDNF) levels were assessed. EAE reduced muscle fiber CSA of TA, EDL and SOL. In general, exercise was not able to affect CSA, whereas it delayed hindquarter paralysis peak. CON muscle work peaked and declined, while it remained stable in EAE. BDNF-responses were not affected by EAE or exercise. In conclusion, EAE affected CSA-properties of TA, EDL and SOL, which could, partly, explain the absence of peak work during isokinetic muscle performance in EAE-animals. However, exercise was not able to prevent muscle fiber atrophy.
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