Title
Antimicrobial assessment of resins from Calophyllum Antillanum and Calophyllum Inophyllum Antimicrobial assessment of resins from Calophyllum Antillanum and Calophyllum Inophyllum
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Pharmacology. Therapy
Source (journal)
Phytotherapy research. - London
Volume/pages
29(2015) :12 , p. 1991-1994
ISSN
0951-418X
ISI
000367905400019
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The Calophyllum genus is well-known for its antimicrobial and cytotoxic activities, and therefore, we analyzed these biological activities for resins of Calophyllum antillanum and Calophyllum inophyllum growing in Cuba. C. antillanum resins showed a potent activity against Plasmodium falciparum (IC50 = 0.3 +/- 0.1 mu g/mL), while its cytotoxicity against MRC-5 cells was much lower (IC50 = 21.6 +/- 1.1 mu g/mL). In contrary, the resin of C. inophyllum showed an unspecific activity. The presence of apetalic acid, isoapetalic acid, calolongic acid, pinetoric acid I, pinetoric acid II, isocalolongic acid, pinetoric acid III, and isopinetoric acid III in C. antillanum resins was also confirmed. These results demonstrated for the first time the potential activity of C. antillanum resins against P. falciparum. Copyright (C) 2015 John Wiley & Sons, Ltd.
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