Title
Colistin-resistant Acinetobacter baumannii clinical strains deficient in biofilm formation
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Washington, D.C. ,
Subject
Biology
Pharmacology. Therapy
Human medicine
Source (journal)
Antimicrobial agents and chemotherapy. - Washington, D.C.
Volume/pages
60(2016) :3 , p. 1892-1895
ISSN
0066-4804
ISI
000376490800093
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In two pairs of clinical colistin-susceptible/colistin-resistant (ColS/ColR) Acinetobacter baumannii, ColR strains showed significantly decreased biofilm formation in static and dynamic assays (P<0.001) and lower relative fitness (P<0.05) compared with ColS. Whole genome sequencing comparison of strain pairs identified in one ColR strain a *241K change in LpsB (involved in LPS synthesis) and in the other, a frameshift mutation in CarO and loss of a 47,969 bp element containing multiple genes associated with biofilm production.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/606de1/131289.pdf
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