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Title
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Colistin-resistant Acinetobacter baumannii clinical strains deficient in biofilm formation
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Author
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Abstract
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| In two pairs of clinical colistin-susceptible/colistin-resistant (ColS/ColR) Acinetobacter baumannii, ColR strains showed significantly decreased biofilm formation in static and dynamic assays (P<0.001) and lower relative fitness (P<0.05) compared with ColS. Whole genome sequencing comparison of strain pairs identified in one ColR strain a *241K change in LpsB (involved in LPS synthesis) and in the other, a frameshift mutation in CarO and loss of a 47,969 bp element containing multiple genes associated with biofilm production. |
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Language
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English
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Source (journal)
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Antimicrobial agents and chemotherapy. - Washington, D.C., 1972, currens
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Publication
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Washington, D.C.
:
American Society for Microbiology
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2016
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ISSN
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0066-4804
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DOI
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10.1128/AAC.02518-15
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Volume/pages
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60
:3
(2016)
, p. 1892-1895
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ISI
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000376490800093
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Full text (Publisher's DOI)
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Full text (open access)
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