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Title
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In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients : hypothesis for a role for immune-inflammatory mechanisms
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Author
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Abstract
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| Recent studies reported over-expression of a cytokine (Interleukin (IL)-18) in the serum of sporadic amyotrophic lateral sclerosis (sALS) patients. Here, we report on the first-time detection of in-situ expression of activated IL-18 in the human brain in sALS patients. We also detected cerebral in-situ expression of key-molecules known to be closely related to the molecular network associated with the activation/secretion of IL-18 cytokine, namely, the receptor-interacting serine/threonine-protein kinase 3 (RIPK3 or RIP3), NOD-like receptor pyrin domain containing 3 (NLRP3)-inflammasome, and activated caspase-1. These findings suggest and allow to hypothesize that there might be a role for this cytokine network in molecular mechanisms associated with or implicated in the physiopathology of this neurodegenerative disorder. |
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Language
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English
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Source (journal)
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Medical hypotheses. - Edinburgh
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Publication
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Edinburgh
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2016
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ISSN
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0306-9877
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DOI
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10.1016/J.MEHY.2015.11.022
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Volume/pages
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86
(2016)
, p. 14-17
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ISI
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000373242100004
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Pubmed ID
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26804591
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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