Title
In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients : hypothesis for a role for immune-inflammatory mechanisms In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients : hypothesis for a role for immune-inflammatory mechanisms
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Edinburgh ,
Subject
Human medicine
Source (journal)
Medical hypotheses. - Edinburgh
Volume/pages
86(2016) , p. 14-17
ISSN
0306-9877
ISI
000373242100004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Recent studies reported over-expression of a cytokine (Interleukin (IL)-18) in the serum of sporadic amyotrophic lateral sclerosis (sALS) patients. Here, we report on the first-time detection of in-situ expression of activated IL-18 in the human brain in sALS patients. We also detected cerebral in-situ expression of key-molecules known to be closely related to the molecular network associated with the activation/secretion of IL-18 cytokine, namely, the receptor-interacting serine/threonine-protein kinase 3 (RIPK3 or RIP3), NOD-like receptor pyrin domain containing 3 (NLRP3)-inflammasome, and activated caspase-1. These findings suggest and allow to hypothesize that there might be a role for this cytokine network in molecular mechanisms associated with or implicated in the physiopathology of this neurodegenerative disorder.
E-info
https://repository.uantwerpen.be/docman/iruaauth/a8a910/131296.pdf
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Handle