Publication
Title
A first step in the quest for the active constituents in Filipendula ulmaria (meadowsweet) : comprehensive phytochemical identification by liquid chromatography coupled to quadrupole-orbitrap mass spectrometry
Author
Abstract
Filipendula ulmaria (meadowsweet) is traditionally used for the treatment of inflammatory diseases and as a diuretic and antirheumatic. Extracts of Filipendulae herba are on the market in the European Union as food supplements. Nevertheless, its active constituents remain to be revealed. During this study, the phytochemical composition of Filipendulae Ulmariae Herba was comprehensively characterised for the first time with two complementary generic ultrahigh-performance liquid chromatography-photodiode array-accurate mass mass spectrometry methods. Selective ion fragmentation experiments with a hybrid quadrupole-orbital trap mass spectrometer significantly contributed to compound identification: a total of 119 compounds were tentatively identified, 69 new to F. ulmaria. A rich diversity of phenolic constituents was detected and only a few non-phenolic phytochemicals were observed. Metabolisation and pharmacological studies should be conducted to investigate which of these constituents or metabolites there of contribute to the activity of F. ulmaria after oral intake.
Language
English
Source (journal)
Planta medica: natural products and medicinal plant research. - Stuttgart
Publication
Stuttgart : 2016
ISSN
0032-0943
Volume/pages
(2016), p. 1-15
ISI
000374775900008
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 25.02.2016
Last edited 12.04.2017
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