Title
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Shear stress metrics and their relation to atherosclerosis : an in vivo follow-up study in atherosclerotic mice
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Author
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Abstract
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It is generally accepted that low and oscillatory wall shear stress favors the initiation and development of atherosclerosis. However, a quantitative analysis of the association between shear stress metrics at baseline and lesion prevalence at a later stage is challenging to perform in vivo on a within-subject basis. In this study, we assessed carotid hemodynamics and derived hemodynamic wall parameters from subject-specific fluidstructure interaction simulations in the left and right carotid arteries of 4 ApoE−/− mice prior to disease development. We then applied a point-by-point quantitative association (surrogate sample data analysis) between various established and more recent shear related parameters and the extent of macrophage infiltration at a later stage. We conclude that, for the atherosclerotic murine carotid bifurcation, (i) there is an association between hemodynamics and macrophage infiltration; (ii) this correlation is most apparent when assessed at the level of the entire carotid bifurcation; (iii) the strongest spatial correlation between hemodynamics and atherosclerosis development was found for the time averaged wall shear stress (negative correlation) and the relative residence time (positive correlation); (iv) aggregating the data leads to an overestimation of the correlation. |
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Language
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English
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Source (journal)
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Annals of biomedical engineering. - New York, N.Y.
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Publication
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New York, N.Y.
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2016
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ISSN
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0090-6964
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DOI
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10.1007/S10439-015-1540-Z
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Volume/pages
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44
:8
(2016)
, p. 2327-2338
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ISI
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000379511100001
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Pubmed ID
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26695938
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Full text (Publisher's DOI)
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