Shear stress metrics and their relation to atherosclerosis : an in vivo follow-up study in atherosclerotic mice
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
New York, N.Y.
Engineering sciences. Technology
Annals of biomedical engineering. - New York, N.Y.
, p. 2327-2338
University of Antwerp
It is generally accepted that low and oscillatory wall shear stress favors the initiation and development of atherosclerosis. However, a quantitative analysis of the association between shear stress metrics at baseline and lesion prevalence at a later stage is challenging to perform in vivo on a within-subject basis. In this study, we assessed carotid hemodynamics and derived hemodynamic wall parameters from subject-specific fluidstructure interaction simulations in the left and right carotid arteries of 4 ApoE−/− mice prior to disease development. We then applied a point-by-point quantitative association (surrogate sample data analysis) between various established and more recent shear related parameters and the extent of macrophage infiltration at a later stage. We conclude that, for the atherosclerotic murine carotid bifurcation, (i) there is an association between hemodynamics and macrophage infiltration; (ii) this correlation is most apparent when assessed at the level of the entire carotid bifurcation; (iii) the strongest spatial correlation between hemodynamics and atherosclerosis development was found for the time averaged wall shear stress (negative correlation) and the relative residence time (positive correlation); (iv) aggregating the data leads to an overestimation of the correlation.