Title
The effect of docetaxel on developing oedema in patients with breast cancer : a systematic review The effect of docetaxel on developing oedema in patients with breast cancer : a systematic review
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Hoboken :Wiley-blackwell ,
Subject
Human medicine
Source (journal)
European journal of cancer care. - Oxford
Volume/pages
25(2016) :2 , p. 269-279
ISSN
0961-5423
ISI
000371475800011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Docetaxel is extensively used in chemotherapy for the treatment of breast cancer. Little attention has been given to oedema as a possible side effect of docetaxel-containing therapies. Until now, no review was conducted to evaluate docetaxel-containing therapies versus docetaxel-free therapies on the magnitude of the risk of developing oedema. In this systematic review, we investigated the risk of developing oedema in patients being treated for breast cancer with or without docetaxel. In this systematic literature review, we searched PubMed and Web of Knowledge for studies on breast cancer patients treated with chemotherapy containing docetaxel. We included clinical trials comparing docetaxel versus docetaxel-free chemotherapy. Oedema had to be reported and measured as a key outcome or an adverse effect. Methodological checklists were used to assess the risk of bias within the selected studies. Seven randomised clinical trials were included. Six trials were of moderate methodological quality. All trials showed an increased rate of oedema in the docetaxel- treatment arm. The trial of weakest methodological quality reported the highest incidence of oedema. The results moderately suggest that adjuvant chemotherapy containing docetaxel is related to a significantly increased risk of developing oedema, compared with docetaxel-free chemotherapy.
E-info
https://repository.uantwerpen.be/docman/iruaauth/84125d/131441.pdf
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