Publication
Title
Evaluation of topical antifungal products in an in vitro onychomycosis model
Author
Abstract
Many topical commercial products are currently available for the treatment of onychomycosis. However, limited data are available concerning their antifungal activity. Using an in vitro onychomycosis model, the daily application of seven nail formulations was compared to the antifungal reference drug amorolfine (Loceryl®) and evaluated for inhibitory activity against Trichophyton mentagrophytes using an agar diffusion test. Of all commercial nail formulations, only Excilor® and Nailner® demonstrated inhibitory activity, which was much lower compared to the daily application of Loceryl®. However, Excilor® showed similar efficacy compared to the conventional weekly application of Loceryl®. These results suggest a role for organic acids in the antifungal effect of Excilor® (acetic acid, ethyl lactate) and Nailner® (lactic acid, citric acid, ethyl lactate) as all tested formulations without organic acids were inactive.
Language
English
Source (journal)
Mycoses: diagnosis, therapy and prophylaxis of fungal diseases. - Berlin
Publication
Berlin : 2016
ISSN
0933-7407
Volume/pages
(2016), p. 1-4
ISI
000373950000009
Full text (Publishers DOI)
Full text (open access)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.03.2016
Last edited 06.05.2017
To cite this reference