Publication
Title
The extracellular matrix protein 1 (ECM1) in molecular-based skin biology
Author
Abstract
Extracellular matrix protein 1 (ECM1) is an 85-kDa secreted glycoprotein that plays a pivotal role in the structural and homeostatic biology of the skin, particularly in the proliferation and differentiation of epidermal keratinocytes, reconstitution of basement membrane, angiogenesis, malignant transformation, and aging. The multifocal interaction of ECM1 with various extracellular matrix and structural molecules is substantiated by loss-of-function mutations in the ECM1 gene in an autosomal recessive genodermatosis lipoid proteinosis and circulating IgG autoantibodies to this molecule in a humoral autoimmune condition lichen sclerosus, both of which are now recognized as an immunogenetic disease counterpart sharing comparable skin pathology. A series of underlying insights for the in vivo ECM1 biology, as a binding core and/or a scaffolding protein, arose not only for wide-ranged differentiation properties of the epidermal keratinocytes, acquisition of immune tolerance and allergic responses via particular T cell subsets such as CD4+ CD25+ regulatory T cells and Th2 cells, and various cancers but also from intrinsic and extrinsic aging of the skin.
Language
English
Source (book)
Textbook of aging skin / Farage, M.A. [edit.]; et al.
Publication
Berlin : Springer Verlag, 2015
ISBN
978-3-642-27814-3
Volume/pages
p. 2-20
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identification
Creation 08.03.2016
Last edited 22.11.2016
To cite this reference