Publication
Title
Kv5, Kv6, Kv8, and Kv9 subunits : no simple silent bystanders
Author
Abstract
Members of the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, collectively identified as electrically silent voltage-gated K+ channel [KvS] subunits) do not form functional homotetrameric channels but assemble with Kv2 subunits into heterotetrameric Kv2/KvS channels with unique biophysical properties. Unlike the ubiquitously expressed Kv2 subunits, KvS subunits show a more restricted expression. This raises the possibility that Kv2/KvS heterotetramers have tissue-specific functions, making them potential targets for the development of novel therapeutic strategies. Here, I provide an overview of the expression of KvS subunits in different tissues and discuss their proposed role in various physiological and pathophysiological processes. This overview demonstrates the importance of KvS subunits and Kv2/KvS heterotetramers in vivo and the importance of considering KvS subunits and Kv2/KvS heterotetramers in the development of novel treatments.
Language
English
Source (journal)
The journal of general physiology. - New York
Publication
New york : Rockefeller univ press, 2016
ISSN
0022-1295
Volume/pages
147:2(2016), p. 105-125
ISI
000369034000002
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
"Silent" voltage-gated K+ channel subunits: analysis of the molecular determinants of modulatory properties and electrically silent behavior and elucidation of the physiological role.
"Silent" voltage-gated K+ channel subunits – no simple silent bystanders: analysis of their pharmacological profile, physiological role and gating mechanism.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 10.03.2016
Last edited 20.11.2017
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