Publication
Title
Priming solutions for cardiopulmonary bypass : comparison of three colloids
Author
Abstract
The present study was designed to compare the differences in the clinical effects of three colloidal solutions, albumin, urea-linked gelatin, and succinyl-linked gelatin, when used as priming fluids for cardiopulmonary bypass (CPB) under α-stat conditions. A consecutive series of 105 patients scheduled for cardiac surgery were randomized into three identically managed groups, except for the CPB prime. Variables relating to acid-base status, oncotic activity, metabolism, coagulation, and postoperative evaluation were measured. Marked differences in acid-base status, colloid osmotic pressure, additional prime requirements, blood lactate, urine output, and the need for buffer solutions occurred among groups, with the succinyl-linked gelatin group having better results than the other groups. Changes in hemodynamics, oxygen consumption, and blood-glucose levels during CPB did not vary among groups. There were also no important intergroup differences in hematologic and clotting variables or postoperative parameters such as blood loss or use of blood products. Electrolyte changes were similar except for a significant increase in ionized calcium that occurred in the urea-linked gelatin group after bypass. The results indicate that succinyl-linked gelatin is an adequate and safe alternative to human albumin for use as a colloid during CPB under α-stat conditions.
Language
English
Source (journal)
Journal of cardiothoracic and vascular anesthesia. - Philadelphia, Pa
Publication
Philadelphia, Pa : 1991
ISSN
1053-0770
Volume/pages
5:5(1991), p. 457-466
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Affiliation
Publications with a UAntwerp address
External links
Record
Identification
Creation 08.10.2008
Last edited 22.11.2016
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