Title
Linking <tex>$CD11b^{+}$</tex> dendritic cells and natural killer T cells to plaque inflammation in atherosclerosisLinking <tex>$CD11b^{+}$</tex> dendritic cells and natural killer T cells to plaque inflammation in atherosclerosis
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Antwerp Surgical Training, Anatomy and Research Centre (ASTARC)
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Laboratory Experimental Medicine and Pediatrics (LEMP)
Thorax - en vaatheelkunde
Human molecular genetics
Physiopharmacology (PHAR)
Faculteit Geneeskunde
Publication type
article
Publication
Oxford,
Subject
Biology
Human medicine
Source (journal)
Mediators of inflammation. - Oxford
Volume/pages
(2016), p. 1-12
ISSN
0962-9351
0962-9351
Article Reference
6467375
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Atherosclerosis remains the leading cause of death and disability in our Western society. To investigate whether the dynamics of leukocyte (sub)populations could be predictive for plaque inflammation during atherosclerosis, we analyzed innate and adaptive immune cell distributions in blood, plaques, and lymphoid tissue reservoirs in apolipoprotein E-deficient (ApoE−/−) mice and in blood and plaques from patients undergoing endarterectomy. Firstly, there was predominance of the CD11b+ conventional dendritic cell (cDC) subset in the plaque. Secondly, a strong inverse correlation was observed between CD11b+ cDC or natural killer T (NKT) cells in blood and markers of inflammation in the plaque (including CD3, T-bet, CCR5, and CCR7). This indicates that circulating CD11b+ cDC and NKT cells show great potential to reflect the inflammatory status in the atherosclerotic plaque. Our results suggest that distinct changes in inflammatory cell dynamics may carry biomarker potential reflecting atherosclerotic lesion progression. This not only is crucial for a better understanding of the immunopathogenesis but also bares therapeutic potential, since immune cell-based therapies are emerging as a promising novel strategy in the battle against atherosclerosis and its associated comorbidities. The cDC-NKT cell interaction in atherosclerosis serves as a good candidate for future investigations.
Full text (open access)
https://repository.uantwerpen.be/docman/ua/06f659/11197.pdf
https://repository.uantwerpen.be/docman/irua/07ccc8/131723.pdf
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