Title
Semicircular canal fibrosis as a biomarker for lateral semicircular canal function loss Semicircular canal fibrosis as a biomarker for lateral semicircular canal function loss
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Lausanne :Frontiers Research Foundation ,
Subject
Human medicine
Source (journal)
Frontiers in neurology / Frontiers Research Foundation (Lausanne, Switzerland) - Lausanne, 2010, currens
Volume/pages
7(2016) , p. 1-5
ISSN
1664-2295
1664-2295
Article Reference
43
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background and purpose: Radiological abnormalities at the level of the semicircular canals are frequently observed without known correlation to a pathologic condition or function. They include narrowing or sclerosis on computed tomography (CT) and narrowing or signal loss on T2-weighted magnetic resonance imaging (MRI). Our hypothesis was that these radiological abnormalities at the level of the semicircular canals reflect an aspecific but advanced stage of vestibular decay. Materials and methods: Retrospective study in 35 consecutive patients with bilateral profound deafness eligible for cochlear implantation. Electronystagmography, CT, and MRI were performed as part of evaluation for cochlear implant candidacy. Results: In our population, 31.4% had a bilateral lateral semicircular canal function loss, while 11.4% had a unilateral lateral semicircular canal function loss. CT-scan abnormalities did not correlate to lateral semicircular canal function loss at a statistically significant level. However, abnormalities observed on MRI correlated significantly with ipsilateral lateral semicircular canal function loss. This statistically significant difference was present not only if abnormalities were observed in at least one of the semicircular canals but also if we studied the posterior, superior, and lateral semicircular canals separately. Conclusion: Semicircular canal abnormalities on T2-weighted MRI (including narrowing and/or signal loss in one or more semicircular canals) are correlated to lateral semicircular canal function loss.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/2dc6b0/132097.pdf
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